Collagen Matters
• As we grow older, our skin undergoes structural changes at every layer.
• Bone resorption occurs, ligaments loosen, the epidermis becomes thinner, the subcutaneous fat layer diminishes, and the number of fibroblasts — cells responsible for producing collagen, elastin fibers, and hyaluronic acid — decreases.
• Consequently, collagen synthesis declines, leading to visible skin aging such as sagging, loss of firmness, and facial laxity.
• Therefore, do not overlook the importance of collagen. It plays a crucial role in maintaining skin integrity and elasticity. As collagen levels decline with age, the skin becomes thinner, more fragile, and prone to wrinkles and fine lines.
• This is why modern science and aesthetics have continuously developed new products and technologies that stimulate collagen production, helping the skin remain firm, resilient, and youthful.
What is HArmonyCA and What Does It Contain?
• HArmonyCA is an innovative injectable treatment that functions as both a dermal filler and a biostimulator, developed by Allergan, a leading global pharmaceutical company.
• In simpler terms, it is a hybrid filler that combines the unique properties of two active ingredients: Hyaluronic Acid (HA) and Calcium Hydroxyapatite (CaHA).
• Calcium Hydroxyapatite (CaHA) is a naturally occurring mineral found in the human body — in bones, teeth, and nails. Clinical studies have shown that CaHA stimulates fibroblasts, the cells that produce collagen, to create new collagen fibers and enhance facial firmness. Unlike polymer-based stimulants such as PDLLA or PLLA, CaHA promotes natural collagen stimulation for smooth, natural-looking results without excessive inflammation.
• Hyaluronic Acid (HA) is a naturally occurring substance within the skin that retains moisture and provides smoothness, plumpness, and elasticity. In aesthetics, HA is widely used as a filler to restore lost volume and improve facial contours.
How Does HArmonyCA Work?
• HArmonyCA offers dual-action (Duo Effects) results by combining two natural substances:
- Hyaluronic Acid (HA) – Acts as a carrier for CaHA and provides instant lifting effects from the very first day of treatment. HA penetrates deep into the skin to fill wrinkles, restore volume, and create a firmer, lifted facial contour with smoother skin texture.
- Calcium Hydroxyapatite (CaHA) – Provides long-term skin firmness by stimulating collagen production over time. Newly formed collagen fibers gradually strengthen the skin’s structure, resulting in a progressive and long-lasting lifting effect. Naturally, CaHA remains active for approximately 1–3 years before being absorbed by the body.
How Long Does HArmonyCA Last and How Often Should It Be Done?
• The results of HArmonyCA last approximately 18–24 months, thanks to its dual-action mechanism combining HA and CaHA that continuously stimulate natural collagen production over time.
• However, results vary depending on individual factors such as age, skin condition, and skincare habits. In the first month, patients will notice the lifting and volumizing effect from Hyaluronic Acid, followed by the gradual collagen stimulation effect of CaHA, which continues to improve the skin’s firmness and structure.
• In general, treatment is recommended once every 1–2 years. For even longer-lasting results, HArmonyCA can be combined with other aesthetic procedures, along with a healthy lifestyle and proper skin maintenance.
Who Is HArmonyCA Suitable For? What Age Is Appropriate?
HArmonyCA is ideal for individuals who:
• Experience sagging or loss of skin firmness
• Have collagen loss and want to restore facial volume
• Have loose or inelastic skin
• Have nasolabial folds or marionette lines
• Desire to enhance facial volume or correct sunken cheeks
• Have facial imbalance or asymmetry
• Want a sharper jawline and clearer facial definition
• Want immediate visible results with minimal downtime
HArmonyCA is not limited by age — it depends on the condition of the skin. Anyone experiencing the above issues can receive the treatment after consultation with a qualified physician.
Which Areas Can HArmonyCA Be Injected?
• HArmonyCA can be injected along the sides of the face, from the area in front of the ear to the hairline and jawline, to lift sagging skin and redefine facial contours.
• It can also be applied to the cheeks to enhance fullness and improve skin elasticity, as well as the chin and jawline for a slimmer and more balanced appearance.
• The injection should be performed beneath the dermis, where collagen stimulation is most effective, promoting firmness and long-term rejuvenation.
• Each treatment plan should be customized by a certified aesthetic physician to ensure safe, accurate, and natural results tailored to individual facial anatomy.
How Is HArmonyCA Different from Other Fillers or Injectable Treatments?
• Traditional Hyaluronic Acid Fillers share some similarities with HArmonyCA, but they contain only HA and do not include CaHA. Therefore, HArmonyCA provides both instant lifting and long-term collagen stimulation, offering a more comprehensive rejuvenation outcome.
• Radiesse consists solely of Calcium Hydroxyapatite (CaHA), which primarily focuses on collagen production and skin quality improvement. It can be injected in multiple areas of the face and body (such as hands and neck) but does not provide the immediate volumizing and moisturizing benefits of HA.
• Sculptra contains Poly-L-lactic acid (PLLA), a collagen stimulator that works gradually. It requires 2–3 sessions spaced 4–6 weeks apart, with visible results developing over 2–3 months. While Sculptra is ideal for long-term collagen enhancement, HArmonyCA provides both immediate lifting and more precise contouring due to the presence of HA.
• Profhilo uses non-crosslinked Hyaluronic Acid to smooth the skin surface, enhance hydration, and improve fine lines. It typically lasts 6–12 months. By contrast, HArmonyCA works at a deeper skin level, strengthening the structural foundation of the skin while lifting and stimulating collagen for longer-lasting results.
Can HArmonyCA Be Combined with Other Treatments, Such as Botox?
• Yes. HArmonyCA can safely be combined with other aesthetic treatments when planned by a qualified physician.
• It can be administered alongside Botox or other Fillers, as each treatment targets different skin layers and serves complementary purposes.
• It can also be combined with energy-based devices such as RF, HIFU, or Oligio — these should be performed before the injection.
• In addition, non-ablative laser treatments can be performed on the same day, typically before HArmonyCA injection.
How to Prepare Before HArmonyCA Injection
Preparation for HArmonyCA is similar to filler or Botox procedures:
• Choose a certified clinic and a qualified, experienced physician who uses authentic products.
• Discontinue supplements that may cause bruising, such as fish oil and vitamin E, at least 5–7 days before treatment.
• Avoid NSAIDs or blood-thinning medications (e.g., ibuprofen, aspirin) unless advised by your primary physician.
• Avoid alcohol for at least 24 hours prior to the procedure.
• Inform your doctor of any medical conditions or allergies.
• The injection area should be free from swelling, inflammation, or infection. Notify your physician if such symptoms occur before treatment.
Post-Treatment Care After HArmonyCA Injection
Aftercare is similar to other biostimulatory filler treatments:
• Avoid intense exercise, saunas, or activities causing excessive sweating for 24–48 hours after treatment.
• Do not massage or press the treated area for 1–2 weeks.
• Apply cold compresses during the first 24 hours to reduce swelling.
• Avoid facial lasers or skin treatments for 1–2 weeks unless approved by your physician.
• Refrain from eating fermented foods, seafood, or spicy and salty dishes for 1–2 weeks to minimize swelling.
Does HArmonyCA Hurt?
• HArmonyCA has been clinically studied for injection comfort by evaluating its osmolarity — the concentration of solutes in a solution.
• Research shows that substances with osmolarity levels close to blood plasma and vessel walls reduce pain and irritation. HArmonyCA has an osmolarity of 330 mOsm/mg, which is within the optimal range, minimizing discomfort.
• It also contains Lidocaine, a local anesthetic that helps reduce pain and stinging during the procedure. Combined with pre-treatment numbing cream, patients experience minimal discomfort during injection.
Distinctive Features of HArmonyCA
Advanced Crosslinking Technology
HArmonyCA is developed using proprietary crosslinking technology, a modern manufacturing process that enhances product stability, consistency, and efficacy. This ensures safe, effective, and natural-looking results.
Smooth and Uniform Microspheres
Under electron microscopy, the CaHA microspheres in HArmonyCA are smooth, spherical particles sized 25–45 microns, the ideal size for stimulating collagen. These particles are evenly dispersed within the HA gel, ensuring a consistent injection and natural result.
User-Friendly Prefilled Syringe
HArmonyCA is designed in prefilled syringes for ease of use, minimizing preparation time. Each box contains two 1.25 cc syringes, pre-mixed with Lidocaine for added comfort.
Minimal Discomfort
With its optimal osmolarity (330 mOsm/mg), HArmonyCA provides a comfortable injection experience with less irritation and pain.
High Elasticity (G’ Value)
HArmonyCA possesses a high elastic modulus (G’) similar to Juvederm Volux, providing excellent lift and facial contour definition.
Long-Lasting Lifting Effect
Visible lifting can be seen within the first week, and the effect continues to improve and maintain firmness over time, offering results that last longer than most fillers available today.
Advantages of the HArmonyCA (HACa) Program
💙 Seamlessly integrates with skin for a smooth, even finish.
🧡 Provides an immediate lifting effect from the very first session.
💙 Works safely without triggering inflammation.
🧡 Stimulates collagen production beneath the skin, resulting in firm, long-term tightening.
💙 Has osmolarity close to blood and cell membranes, causing minimal irritation during injection.
🧡 Reduces fine lines, restores youthful collagen, and enhances facial contouring simultaneously.
When Can Energy-Based Devices (e.g., HIFU) Be Performed After HArmonyCA?
• It is recommended to wait at least 3–4 weeks before undergoing energy-based treatments such as HIFU, Ulthera, Oligio, or Thermage, to allow the filler to fully integrate into the skin.
• The heat levels produced by these devices are safe and do not dissolve HA or CaHA within the skin.
Which Skin Types Are Suitable for HArmonyCA? Can Oily Skin Receive the Treatment?
• HArmonyCA is suitable for all skin types, including oily skin, as collagen loss occurs regardless of skin type due to aging and environmental factors.
• Its ingredients — HA and CaHA — are biocompatible and naturally found in the human body, ensuring high safety and compatibility with human tissue.
